26 February 2025, New Delhi: DHODH inhibitors, which target dihydroorotate dehydrogenase in fungi, are a valuable class of fungicides used to control a range of fungal diseases. This group plays a key role in inhibiting de novo pyrimidine biosynthesis in pathogens, a vital process for their survival. However, their efficacy is threatened by medium-to-high resistance risk in fungal populations.
Resistance management for DHODH inhibitors requires careful monitoring and integrated pest management strategies. Rotating fungicide groups and mixing DHODH inhibitors with fungicides that have complementary modes of action can help slow down the development of resistant strains.
Farmers should apply DHODH inhibitors with caution, ensuring that they are part of a broader disease management plan that incorporates biological and cultural controls, in addition to chemical treatments.
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