Understanding Dihydroorotate Dehydrogenase Inhibitors in Fungicide Resistance

26 February 2025, New Delhi: Introduction to DHODH Inhibitors

Dihydroorotate dehydrogenase (DHODH) inhibitors are a class of fungicides that disrupt the de novo pyrimidine biosynthesis pathway in fungi. This interference halts fungal growth by preventing the production of essential components for DNA and RNA synthesis. DHODH inhibitors like ipflufenoquin are vital in controlling certain fungal diseases, but they are not without their risks.

Resistance Risks and Management

DHODH inhibitors present medium to high resistance risks. Fungal pathogens may evolve mechanisms to bypass the inhibition of pyrimidine biosynthesis, rendering the fungicides less effective. Resistance management is therefore crucial for ensuring the continued efficacy of these chemicals. FRAC has highlighted the need for proactive resistance management strategies, which include rotating fungicides and integrating other forms of disease control.

Ensuring Long-Term Effectiveness

For DHODH inhibitors to remain effective, resistance management strategies must be carefully followed. By incorporating cultural practices, rotating fungicide classes, and following FRAC guidelines, the risk of resistance can be minimized. These measures ensure that DHODH inhibitors continue to protect crops from fungal infections in the long term.

Also Read: Low Water, High Risk? Why Drone-Based Pesticide Spraying Raises Concerns

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